Patrick Dempsey & Isaiah Washington

While some feuds only involve nasty verbal exchanges, others become unforgettable for being physical. That was allegedly what happened between Patrick Dempsey and Isaiah Washington on the set of Grey’s Anatomy in 2006. Reports claimed that the brawl started when the discussion on late actors got heated.

Washington also allegedly said nasty things against one of the cast members, T.R. Knight, which led to his exit from the show. We’re unsure if the trio mended their fences, but it is worth noting that Washington resurrected his feud with another Grey’s Anatomy star, Katherine Heigl, in November 2020.